Post image for Alzheimer’s Association Releases its 2014 Facts, Figures and Video

The Alzheimer’s Association annually releases the latest facts and figures about the disease.  In case you have not seen it yet, I’m posting their 2014 video, which will take you less than two minutes to view.  As usual, the video is incredibly moving.

In my view, the Alzheimer’s Association is the thought leader for bringing this disease to the forefront.

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One new focus in this year’s report is on the impact the disease has on women. Did you know, for instance, more than 60 percent of Alzheimer’s caregivers are female?  Actually, I think that number has been decreasing as more men step into care giving rolls.

Of course, those of us in the Alzheimer’s universe already know that more women get the disease and (still) many more women than men are caregivers.  Even so, I’m glad to see females highlighted in the report, video and the accompanying infographic.  It clearly shows women are at center of this epidemic.

For more information and to look at the entire 2014 report, please go to this page on the Alzheimer’s Association website.

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Post image for Alzheimer’s Disease and the Early-Onset Colombian Connection

I’m a huge fan of the CBS news show Sunday Morning.  It’s 90 minutes of quality programming that I look forward to every week.

This week’s Sunday Morning cover story was about Alzheimer’s disease.  Titled, How One Family May Raise Hope for Alzheimer’s Patients, it was reported by Mo Rocca, one of the my favorite reporters.  The nine-minute segment focused on the inherited early-onset Alzheimer’s that has been identified in a large, extended family in Colombia, near or around the city of Medellin.

There are approximately 5,000 family members and all are descended from one Basque couple who settled in Colombia in the 1700s.  Genetic testing show an astounding one-third of the family carry a mutated gene that has been identified as the culprit in passing along the early-onset Alzheimer’s.  Those who get the disease often begin showing symptoms in their 40s.

Scientists, most notably from the Banner Institute in Phoenix, Arizona, have been studying these familial links for many years.

Researchers first created an extensive family tree, a huge undertaking.  Then, the gene had to be identified, a process that took a decade.  Next, they analyzed the DNA of 3,300 family members.

While all this was happening, the team of scientists were searching for a drug company to participate and pony up for some huge drug trial costs.  Genentech finally signed on and their drug, Crenezumab was selected for the trial.  One of the study leaders is Dr. Francisco Lopera, a Colombian neurologist.

Studying this Colombian family allows researchers to work with those who have the mutated gene for early-onset Alzheimer’s, but before these individuals develop any signs of dementia.

Since this Colombian family was first identified, researchers have learned a great deal about the brain and about Alzheimer’s disease.

For example, it is now understood the disease can take many years to manifest.  An individual may have the beginnings of Alzheimer’s but show no outward signs or symptoms for a decade or even two or three.

Additionally, scientists were once convinced the disease was caused by a massive build-up of Beta-amyloid plaques and tau proteins, often referred to as the hallmark traits when a diseased brain is autopsied.  Some researchers now believe that while plaque and protein destroy brain cells, they are a by-product and not the root cause of the disease.

In Colombia, researchers are testing new, experimental plaque-reducing medications on 300 healthy adult family members.  A smaller study, using the same criteria, is simultaneously being conducted in the U.S.  You may learn more by visiting the Universidad de Antioquia website.

If these drugs are successful, this double-blind, five-year study will control the plaque build-up and (hopefully) stave off Alzheimer’s for participants.

However, another, and very unwanted, result could be this: The drugs are successful at eradicating plaque deposits and stopping any new build-up, however the individual still develops Alzheimer’s disease.  This outcome would no doubt send researchers back to the drawing board.

The wheels of research move slowly and sometimes the results lead to a dead end.  I sincerely hope this is not the case this time.

Photo Purchased from iStockPhoto

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Caregiver Quandry: What to Buy for Mother’s Day When Mom Has Alzheimer’s Disease?

April 9, 2014
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Mother’s Day, always the second Sunday in May in the U.S., falls on May 11th this year.  This means you have a little more than a month to pick out that perfect piece of jewelry or perhaps the ideal perfume.  It’s estimated Americans will spend upwards of $2.6 billions on Mother’s Day flowers and an […]

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Could Identical Twins Help Unlock the Mystery of Alzheimer’s?

April 7, 2014
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There is the saying in the Alzheimer’s community, If you met one person with Alzheimer’s disease, then you have met one person with Alzheimer’s disease. In other words, the disease seems to follow no one path and affects everyone differently.  However, a recent comparison of identical twins may debunk this conventional thinking. Part of a […]

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Alzheimer’s Tool Kit for Caregivers. Cool Graphic With Tips and Ideas for Caregivers

March 26, 2014
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If you’re caring for someone with dementia symptoms you’ll already be aware of the complex challenges it presents. People with Alzheimer’s or other forms of dementia are affected by a range of symptoms, including memory loss, difficulty communicating, changes in mood, agitation, depression, physical issues and so much more. These symptoms are not just difficult […]

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In Spite of MNSure Website Massive Fail, I Now Have Obamacare Health Coverage

March 24, 2014
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On Friday, with the help of two highly capable individuals from the Minnesota legislature, I was finally able to obtain my affordable medical coverage.  Their assistance and follow through is most appreciated. After five long months, I was finally able cross MNsure off my to-do list.  Those of you who read Dating Dementia may remember […]

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